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This mechanism is particularly relevant for Indian skin tones, where UV exposure and pollution significantly accelerate pigmentation concerns

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Amino acid transporter mRNA followed similar patterns

These abnormalities were previously regarded as secondary epiphenomena of metabolic dysfunction, but accumulating evidence now indicates that they arise from hyperglycaemia-driven OCTN2 impairment, insulin resistance, and oxidative stress, together forming a distinct carnitine-related metabolic signature